Expression and prognostic significance of APAF-1, caspase-8 and caspase-9 in stage II/III colon carcinoma: Caspase-8 and caspase-9 is associated with poor prognosis
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چکیده
منابع مشابه
The effects of indirect exposure of nanosilver on caspase-8 and caspase-9 levels in liver and brain of suckling rats
Objective(s): The adverse health effects of nanosilver (AgNp) on adult animal models have been well documented. However, data is scarce regarding the toxic effects of AgNp on sensitive developmental stages. The present study aimed to investigate the effects of maternal milk exposure to AgNp on apoptosis induction in the liver and brain of the offspring of rats. Materials and Methods: Lact...
متن کاملFSH and eCG impact follicles development and expression of ovarian FSHR and caspase-9 in mice
The study aimed to investigate the effects of FSH and eCG on the ovarian and follicular development, expression levels of FSHR and caspase-9 of ovaries in vivo. One hundred and five prepuberty mice were allocated into FSH-1, FSH-2, FSH-3, eCG-1, eCG-2, eCG-3 groups and control group (CG). Mice in FSH-1, FSH-2 and FSH-3 were intramuscularly injected with 5, 10 and 20 IU FSH twice (on day 0 and 4...
متن کاملInterval Training Intensity and the Expression of Caspase-9 in Obese Rats with Myocardial Infarction
Objective: Physical exercise reduces myocardial apoptosis but its molecular process is unclear yet. The activated Caspase-9 has a key role in advancing the process of apoptosis. The aim of this study was to evaluate the effect of aerobic interval training intensity on the process of apoptosis in the 10-week male obese wistar rats with myocardial infarction. Materials and Methods: In this clini...
متن کاملCaspase-9 and APAF-1 form an active holoenzyme.
Autocatalytic activation of initiator caspases is the link between pro-apoptotic signals and the destruction machinery of apoptosis. Activation of caspase-9, which mediates oncogene and drug-induced apoptosis, requires binding to the protein APAF-1. We found that the proteolytic activity of caspase-9 in a complex with APAF-1 is several orders of magnitude higher than that of the free enzyme. Th...
متن کاملCaspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells.
Oxidative stress is known to be involved in a variety of pathological processes including atherosclerosis, diabetes, and neurodegenerative diseases. Understanding how intracellular signaling pathways respond to oxidative stress will have a significant implication in the therapy of these diseases. In this study, we applied hydrogen peroxide (H(2)O(2)) to trigger apoptosis and investigated the dy...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2009
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.25111